Beyond Collagen: Why the Real Aging Focus Should Be DNA Damage from NAD⁺ Decline
For years, collagen has dominated the anti-aging market, from powders and serums to cosmetic procedures promising smoother, more youthful skin. While collagen does support skin elasticity and structural integrity, its benefits remain mostly cosmetic. True aging, however, begins much deeper, at the cellular and genetic level. The real focus of advanced anti-aging medicine today is NAD⁺ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for DNA repair, mitochondrial function, and longevity.
At iD CLINICA, we offer medical-grade NAD⁺ injection therapy - a cellular-level treatment that targets the root causes of aging, not just its surface symptoms.
NAD⁺ exists in every cell of the human body and fuels essential biological functions, including DNA repair, energy metabolism, gene regulation, and immune resilience. However, as we age, our NAD⁺ levels decline significantly, by as much as 50% between the ages of 40 and 60 (Gomes et al., 2013). This loss has profound consequences: DNA damage accumulates, mitochondrial function weakens, and inflammatory processes increase. These changes are key drivers of age-related fatigue, brain fog, metabolic decline, and visible aging.
While collagen helps skin look younger, NAD⁺ helps cells function younger. NAD⁺ activates enzymes like PARPs and Sirtuins, both critical for repairing DNA and regulating aging-related genes. When NAD⁺ is depleted, these enzymes shut down, accelerating the aging process. In fact, animal studies have shown that replenishing NAD⁺ levels can reverse signs of aging, improve stem cell function, and extend lifespan (Zhang et al., 2016). Furthermore, NAD⁺ has been linked to enhanced neurological protection and cognitive performance, benefits collagen simply cannot deliver (Verdin, 2015).
At iD CLINICA, we specialise in NAD⁺ injection therapy, which delivers the molecule directly into the bloodstream for maximum absorption and rapid effect. Unlike oral NAD⁺ precursors (such as NMN or NR), which must first be converted by the body and may have inconsistent bioavailability, NAD⁺ injections bypass the digestive system entirely. This ensures your cells get exactly what they need, faster and more efficiently.
To compare NAD⁺ therapy with traditional collagen supplementation, consider the following table:
|
Feature |
Collagen Supplements |
NAD⁺ Injections |
|
Primary Function |
Structural skin and joint support |
Cellular energy, DNA repair, longevity |
|
Effect on DNA Repair |
No impact |
Direct activation of DNA repair enzymes |
|
Mechanism of Action |
Cosmetic and structural |
Biochemical and genetic |
|
Time to See Results |
Weeks to months |
Often within days |
|
Bioavailability |
Variable to Poor (depends on digestion) |
High (100% absorption via bloodstream) |
|
Scientific Backing |
Moderate (mostly skin-focused) |
Extensive (cellular aging, cognition, metabolism) |
Patients at iD CLINICA frequently report benefits such as improved energy, mental clarity, better sleep, mood balance, and faster recovery within just days of beginning treatment. For those experiencing chronic fatigue, stress, burnout, or general signs of aging, NAD⁺ injections offer a therapeutic approach based on cutting-edge molecular science.
This therapy is not limited to those seeking anti-aging benefits. Athletes, professionals under high stress, and individuals recovering from illness or surgery have turned to NAD⁺ to boost immune resilience, accelerate healing, and restore baseline performance. Because NAD⁺ plays such a central role in energy metabolism and DNA repair, it is considered one of the most powerful tools in regenerative and preventive medicine.
As we learn more about how aging actually occurs, not just in the skin, but in the mitochondria, DNA, and gene networks, it becomes clear that collagen is only part of the picture. If you're investing in your long-term health, vitality, and resilience, the real work begins at the cellular level. And that’s where iD CLINICA’s NAD⁺ injection therapy offers a transformative edge.
You don’t age because you stop producing collagen, you age because your cells lose the ability to repair themselves. With targeted NAD⁺ support, those cellular repair pathways can be reactivated, allowing your body to recover, regenerate, and perform at a more youthful level.
If you're ready to go beyond surface-level solutions and support your body from the inside out, book FREE TRAINING at iD CLINICA today.
Let’s move beyond short-term cosmetic fixes. Let’s activate true cellular rejuvenation.
References
Gomes, A.P., Price, N.L., Ling, A.J.Y., Moslehi, J.J., Montgomery, M.K., Rajman, L., White, J.P., Teodoro, J.S., Wrann, C.D., Hubbard, B.P., Mercken, E.M., Palmeira, C.M., de Cabo, R., Rolo, A.P., Turner, N. and Sinclair, D.A., 2013. Declining NAD⁺ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), pp.1624–1638. https://doi.org/10.1016/j.cell.2013.11.037
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E.R., Lutolf, M.P., Aebersold, R., Schoonjans, K., Menzies, K.J. and Auwerx, J., 2016. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), pp.1436–1443. https://doi.org/10.1126/science.aaf2693
Verdin, E., 2015. NAD⁺ in aging, metabolism, and neurodegeneration. Science, 350(6265), pp.1208–1213. https://doi.org/10.1126/science.aac4854