Polynucleotides are rapidly becoming one of the most talked-about regenerative aesthetic treatments in modern skin rejuvenation, and for good reason. Designed to support collagen production, improve skin quality, reduce inflammation and enhance cellular repair, iD CLÍNICA iDPN 2% Polynucleotides have been developed for practitioners looking to offer evidence-led regenerative treatments with exceptional versatility.

The iD CLÍNICA iDPN combines advanced polynucleotide technology with a clinically focused protocol suitable for multiple treatment areas including the face, neck, décolletage and hands. 

What Are Polynucleotides?

Polynucleotides (PN) are purified DNA fragments derived from salmon DNA using enzymatic purification and hydrolysis processes. The manufacturing process removes proteins, lipids and cellular impurities to create a sterile, highly purified 2% PN solution suitable for cosmetic and clinical use. 

The final formulation contains approximately 20 mg/mL of polynucleotides in a sterile physiological solution. 

Unlike traditional skin boosters that primarily focus on hydration, polynucleotides are designed to support cellular regeneration and tissue repair through multiple biological pathways

How iDPN Polynucleotides Work

A2A Receptor Signalling and Skin Repair

Following injection, polynucleotides gradually break down into nucleotides and nucleosides, particularly adenosine. Adenosine interacts with A2A receptors found on dermal fibroblasts, keratinocytes, endothelial cells and immune cells. 

This signalling pathway helps shift skin cells into a more regenerative state, supporting:

• Cellular repair
• Fibroblast stimulation
• Tissue regeneration
• Improved extracellular matrix support

Increased Collagen and Elastin Production

One of the key benefits of iDPN Polynucleotides is their effect on dermal fibroblasts. According to the presentation material, A2A receptor signalling increases the expression of proteins involved in matrix formation, including: 

• Collagen Type I
• Collagen Type III
• Fibronectin
• Elastin

At the same time, polynucleotides may help reduce matrix degradation by suppressing matrix metalloproteinases including MMP-1 and MMP-3. 

The overall effect is:

More collagen production with less collagen breakdown.

This makes polynucleotides particularly attractive for patients concerned with:

• Skin laxity
• Fine lines and wrinkles
• Crepey skin
• Loss of elasticity
• Poor skin texture
• Ageing skin quality

Anti-Inflammatory and Regenerative Benefits

Reduced Inflammaging

Chronic low-grade inflammation, often referred to as “inflammaging”, plays a major role in skin ageing.

The iDPN presentation references suppression of pro-inflammatory cytokines including TNF-α and IL-6. 

Reducing inflammatory signalling may help:

• Protect collagen structures
• Preserve the extracellular matrix
• Improve skin resilience
• Support recovery following aesthetic procedures

Mitochondrial Support and Cellular Energy

The presentation also references enhanced mitochondrial function and improved ATP production within skin cells. 

Mitochondria are often referred to as the “powerhouses” of the cell. Supporting mitochondrial function may contribute to:

• Improved skin vitality
• Better regenerative capacity
• Enhanced cellular repair
• Healthier appearing skin

Antioxidant Effects and SIRT1 Preservation

Oxidative stress is one of the major contributors to visible skin ageing.

According to the presentation, polynucleotides may help:

• Reduce reactive oxygen species (ROS)
• Protect DNA and mitochondria
• Preserve SIRT1 activity
• Improve cellular resilience
• Support skin regeneration and repair 

SIRT1 is often associated with cellular repair and longevity pathways, making this an increasingly interesting area within regenerative aesthetics.

Clinical Protocol for iD CLÍNICA iDPN

The recommended protocol within the presentation includes: 

• Injection using a 4 mm mesotherapy needle
• Superficial intradermal injection technique
• Recommended volume of 0.1 - 0.2 mL per injection point
• Treatment intervals every 2-4 weeks
• A recommended course of 3-4 sessions

The treatment is described as suitable for all Fitzpatrick skin types and can be used across the:

• Face
• Neck
• Décolletage
• Hands 

Investment and Treatment Value

The iD CLÍNICA iDPN 2% vial contains 5 mL of product. The presentation references: 

• £114 per vial
• Approximately £22.80 per face when using 10 injection points
• Approximately £2.28 per 0.1 mL

This allows clinics to position polynucleotide treatments as a high-value regenerative treatment while maintaining strong treatment margins.

Free Online and In-Person Training Available

At iD CLÍNICA Professional, practitioner education remains central to every product launch.

Free online and in-person training is available for qualified practitioners wanting to introduce iDPN Polynucleotides into clinical practice. Training covers:

• Polynucleotide science
• Injection protocols
• Treatment planning
• Combination therapies
• Patient selection
• Practical clinical guidance

Ongoing clinical support is also available following training.

Why Clinics Are Choosing iD CLÍNICA iDPN Polynucleotides

Practitioners are increasingly looking for treatments that move beyond temporary hydration and focus on long-term skin regeneration.

iD CLÍNICA iDPN Polynucleotides are designed to support:

• Skin regeneration
• Collagen stimulation
• Anti-inflammatory support
• Improved elasticity and texture
• Cellular repair pathways
• Overall skin quality improvement

For clinics wanting to expand into regenerative aesthetics with strong educational support and clinically focused protocols, iDPN Polynucleotides represent a compelling addition to treatment offerings.